Schipper H I, Bardosi A, Jacobi C, Felgenhauer K
Department of Neurology, University of Goettingen, Germany.
Neurology. 1988 Mar;38(3):413-6. doi: 10.1212/wnl.38.3.413.
We found that eight of 22 patients with meningeal carcinomatosis from different primary tumors produced local IgG in the CSF, as indicated by elevated IgG index and/or oligoclonal IgG subfractions. Local IgG production, when present, appears in an early stage of the leptomeningeal manifestation and remains detectable over extended observation periods. In autopsied cases with local IgG production, we observed numerous perivascular round-cell infiltrates containing plasma cells and large lymphocytes within the leptomeningeal tumor tissue. After incubation with immunoperoxidase, only these cells showed IgG-specific staining, indicating the site of local IgG production.
我们发现，22例来自不同原发肿瘤的脑膜癌病患者中有8例脑脊液中产生了局部IgG，这由IgG指数升高和/或寡克隆IgG亚组分所表明。局部IgG产生一旦出现，便出现在软脑膜病变的早期阶段，并且在延长的观察期内仍可检测到。在有局部IgG产生的尸检病例中，我们在软脑膜肿瘤组织内观察到大量含有浆细胞和大淋巴细胞的血管周围圆形细胞浸润。用免疫过氧化物酶孵育后，只有这些细胞显示出IgG特异性染色，表明了局部IgG产生的部位。
