Hugon J, Ludolph A, Roy D N, Schaumburg H H, Spencer P S
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Neurology. 1988 Mar;38(3):435-42. doi: 10.1212/wnl.38.3.435.
A primate model of lathyrism has been produced in well-nourished male cynomolgus monkeys chronically fed a fortified diet composed of Lathyrus sativus (chickling or grass pea) and given daily per os an alcoholic extract of this legume. Animals given a diet of non-neurotoxic Cicer arietinum (chick pea) cross-matched with the nutritional properties of the experimental diet served as controls. Another group of animals received the same diet and oral doses of beta, beta'-iminodipropionitrile (IDPN), a reference compound that has been termed an "experimental neurolathyrogen." Monkeys fed Lathyrus developed clinical and electrophysiologic evidence of corticospinal deficits after 3 to 10 months of feeding. Animals administered IDPN showed clinical and/or electrophysiologic changes in the PNS and CNS motor and sensory pathways, and signs of cerebellar dysfunction. Since the two primate disorders are separable on clinical and electrophysiologic grounds, further use of the term "experimental neurolathyrogen" to describe the neurotoxic properties of IDPN seems inappropriate. These findings demonstrate the feasibility of developing a model of early human lathyrism in adequately nourished nonhuman primates.
在营养良好的雄性食蟹猴中建立了一种山黧豆中毒的灵长类动物模型，这些猴子长期食用由山黧豆（鸡豆或草豌豆）组成的强化饮食，并每天经口给予这种豆类的酒精提取物。给予与实验饮食营养特性交叉匹配的非神经毒性鹰嘴豆（鹰嘴豆）饮食的动物作为对照。另一组动物接受相同的饮食并口服β，β'-亚氨基二丙腈（IDPN），一种被称为“实验性神经致病毒素”的参考化合物。喂食山黧豆的猴子在喂食3至10个月后出现了皮质脊髓功能缺损的临床和电生理证据。给予IDPN的动物在周围神经系统和中枢神经系统的运动和感觉通路中出现了临床和/或电生理变化，以及小脑功能障碍的迹象。由于这两种灵长类疾病在临床和电生理方面是可区分的，因此进一步使用“实验性神经致病毒素”一词来描述IDPN的神经毒性特性似乎不合适。这些发现证明了在营养充足的非人灵长类动物中建立早期人类山黧豆中毒模型的可行性。
