Hugon J, Ludolph A C, Spencer P S, Gimenez Roldan S, Dumas J L
Department of Neurology, Limoges University Hospital, France.
Acta Neurol Scand. 1993 Dec;88(6):412-6. doi: 10.1111/j.1600-0404.1993.tb05370.x.
Neurophysiological assessments of central motor pathways were conducted of 11 Spanish subjects with varying degrees of spastic paraparesis (lathyrism). The disease has been induced more than 40 years ago by subsistance on the neurotixic chick pea Lathyrus sativus. Patient evolution was carried out by magnetic cortical and electric spinal stimulations and recordings of the contralateral muscle responses. Central motor conduction times corresponding to lower limbs were clearly more prolonged in those severely affected patients with marked difficulty walking (Stages 4 and 3). Central conduction times corresponding to upper limbs were delayed in only 1 patient. Taken together with clinical and published neuropathological data, these findings suggest that established lathyrism is essentially a central motor system disorder primarily affecting corticospinal tracts regulating the lower limbs.
对11名患有不同程度痉挛性截瘫（山黧豆中毒）的西班牙受试者进行了中枢运动通路的神经生理学评估。这种疾病是40多年前因食用具有神经毒性的鹰嘴豆（山黧豆）而诱发的。通过磁皮层刺激、电脊髓刺激以及对侧肌肉反应记录来跟踪患者病情发展。在那些行走明显困难的严重受影响患者（4期和3期）中，对应下肢的中枢运动传导时间明显延长。只有1例患者对应上肢的中枢传导时间延迟。结合临床和已发表的神经病理学数据，这些发现表明，已确诊的山黧豆中毒本质上是一种主要影响调节下肢的皮质脊髓束的中枢运动系统疾病。
