Akaishi T, Robbins A, Sakuma Y, Sato Y
Department of Physiology, Niigata University School of Medicine, Japan.
Neurosci Lett. 1988 Jan 11;84(1):57-62. doi: 10.1016/0304-3940(88)90337-0.
Extracellular action potentials were recorded from antidromically identified, tonically firing cells in the hypothalamic paraventricular nucleus (PVN) of ovariectomized, estrogen-treated female rats under urethane anesthesia. Genital or somatic sensory stimuli, or electrical stimulation of the nerves innervating the pelvis were applied. Uterine horn or vaginal distension each excited 33% of the neurons tested. Probing of the cervix had no effect. Hindpaw pinch produced excitation in 39% and inhibition in 11% of the neurons tested. Non-noxious somatic stimuli had no effect. Stimulation of the uterine afferent nerves, the hypogastric and pelvic nerves, excited 55% and 30% of the neurons tested, respectively. Stimulation of a somatic nerve of the hindleg, the sciatic nerve, activated 80% of the neurons tested. These results indicate that specific sensory afferents arrive at the PVN from the uterus; in addition, somatic afferents converge in this hypothalamic nucleus.
在氨基甲酸乙酯麻醉下，对切除卵巢并经雌激素处理的雌性大鼠下丘脑室旁核（PVN）中通过逆向鉴定的、持续放电的细胞记录细胞外动作电位。施加生殖器或躯体感觉刺激，或对支配骨盆的神经进行电刺激。子宫角或阴道扩张分别使33%的受试神经元兴奋。宫颈探查无影响。后爪夹捏在39%的受试神经元中产生兴奋，在11%的受试神经元中产生抑制。无害的躯体刺激无影响。刺激子宫传入神经、腹下神经和盆腔神经，分别使55%和30%的受试神经元兴奋。刺激后肢的一条躯体神经坐骨神经，使80%的受试神经元激活。这些结果表明，特定的感觉传入神经从子宫到达PVN；此外，躯体传入神经在这个下丘脑核中汇聚。
