Kannan H, Yamashita H
Brain Res. 1985 Mar 11;329(1-2):205-12. doi: 10.1016/0006-8993(85)90526-8.
Extracellular recordings were made from 607 spontaneously firing neurons within the nucleus tractus solitarius (NTS) and its vicinity in urethane-anesthetized male rats. Following electrical stimulation of the hypothalamic paraventricular nucleus (PVN) area, 21% of the neurons were orthodromically excited, 6% were inhibited and 2.5% were antidromically activated. The antidromic spike latencies were 22-64 ms. Among those orthodromically responding neurons, 81 neurons were tested by pressure pulse stimulation of the isolated carotid sinus. The pressure stimulation produced excitation in 7 and inhibition in 13 neurons. Of the 8 tested neurons which were antidromically activated, one neuron was excited and another neuron inhibited by the pressure pulse stimulation. These results provide electrophysiological evidence for reciprocal connections between neurons in the NTS region and the PVN, and give support to the hypothesis that the PVN is involved in the neural control of the cardiovascular system.
在乌拉坦麻醉的雄性大鼠中，从孤束核（NTS）及其附近的607个自发放电神经元进行细胞外记录。在下丘脑室旁核（PVN）区域进行电刺激后，21%的神经元被顺向兴奋，6%被抑制，2.5%被逆向激活。逆向动作电位潜伏期为22 - 64毫秒。在那些顺向反应的神经元中，81个神经元通过对离体颈动脉窦的压力脉冲刺激进行测试。压力刺激在7个神经元中产生兴奋，在13个神经元中产生抑制。在8个被逆向激活的测试神经元中，一个神经元被压力脉冲刺激兴奋，另一个神经元被抑制。这些结果为NTS区域和PVN中的神经元之间的相互连接提供了电生理证据，并支持PVN参与心血管系统神经控制的假说。
