Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
Graduate Program in Public Health, Center of Health Sciences, State University of Londrina, Londrina, Brazil.
Curr Hypertens Rev. 2021;17(1):14-26. doi: 10.2174/1573402117666210121102405.
Hypertension is an important public health concern that affects millions globally, leading to a large number of morbidities and fatalities. The etiology of hypertension is complex and multifactorial, and it involves environmental factors, including heavy metals. Cadmium and mercury are toxic elements commonly found in the environment, contributing to hypertension. We aimed to assess the role of cadmium and mercury-induced endothelial dysfunction in the development of hypertension. A narrative review was carried out through database searches. In this review, we discussed the critical roles of cadmium and mercury in the etiology of hypertension and provided new insights into potential mechanisms of their effect, focusing primarily on endothelial dysfunction. Although the mechanisms by which cadmium and mercury induce hypertension have yet to be completely elucidated, evidence for both implicates impaired nitric oxide signaling in their hypertensive etiology.
高血压是一个重要的公共卫生关注点，影响着全球数百万人，导致大量的发病率和死亡率。高血压的病因复杂且多因素，涉及环境因素，包括重金属。镉和汞是环境中常见的有毒元素，会导致高血压。我们旨在评估镉和汞引起的内皮功能障碍在高血压发展中的作用。通过数据库检索进行了叙述性综述。在本次综述中，我们讨论了镉和汞在高血压病因学中的关键作用，并提供了对其作用潜在机制的新见解，主要集中在内皮功能障碍上。尽管镉和汞引起高血压的机制尚未完全阐明，但有证据表明两者都涉及一氧化氮信号转导受损在其高血压病因学中。
