Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Medical Oncology, Bern University Hospital, University of Bern, Bern, Switzerland.
Infect Dis (Lond). 2021 Apr;53(4):274-280. doi: 10.1080/23744235.2021.1871642. Epub 2021 Jan 21.
The epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) is not well described.
Our goal was to describe the epidemiology of respiratory virus infections (RVI) in patients undergoing autologous haematopoietic stem cell transplantation (auto-SCT) in a single tertiary centre observation study during two respiratory virus seasons (2015-2017). All symptomatic auto-SCT patients were tested for RVI by nasopharyngeal swab.
156 transplantation episodes were included, 69% were male and, the median age was 57 years. We detected 19 RVIs in 156 transplantation episodes (12%). The median time to RVI after hospitalization was 13 days [IQR 7-13] and 15/19 (79%) had a possible nosocomial origin (occurrence ≥ 5 days after admission). The nosocomial infections included 5/15 (33%) 'severe' RVIs (3 influenza viruses, 1 parainfluenza virus, and 1 adenovirus) as well as 10/15 (66%) non-severe virus infections (including human rhinovirus and human coronavirus).
In approximately 10% of auto-SCT transplantation episodes, an RVI with likely nosocomial origin was detected and included 'severe viruses' such as influenza. Our study suggests that infection prevention measures in auto-SCT patients can be improved.
AdV: adenovirus; ALL: acute lymphatic leukaemia; AML: acute myeloid leukaemia; auto-SCT: autologous haematopoietic stem cell transplantation; hCoV: human coronavirus; HD: Hodgkin's disease; hMPV: human metapneumovirus; HRV: human rhinovirus; HSCT: allogeneic haematopoietic stem cell transplantation; IQR: interquartile range; GCT: germ cell tumour; MM: multiple myeloma; NHL: non-Hodgkin lymphoma; PIV: parainfluenza virus; RSV: respiratory syncytial virus.
自体造血干细胞移植（auto-SCT）患者呼吸道病毒感染（RVI）的流行病学情况尚未得到充分描述。
在两个呼吸道病毒流行季（2015-2017 年）中，我们在一家三级中心进行了一项观察性研究，对所有出现症状的自体造血干细胞移植患者进行了呼吸道病毒检测。通过鼻咽拭子检测患者的呼吸道病毒感染情况。
共纳入 156 例移植病例，其中 69%为男性，中位年龄为 57 岁。我们在 156 例移植病例中检测到 19 例 RVI（12%）。住院后发生 RVI 的中位时间为 13 天[IQR 7-13]，15/19（79%）例可能为医院获得性感染（发病时间在入院后≥5 天）。医院获得性感染包括 5/15（33%）例“严重”RVI（3 例流感病毒、1 例副流感病毒和 1 例腺病毒）和 10/15（66%）例非严重病毒感染（包括人鼻病毒和人冠状病毒）。
约 10%的自体造血干细胞移植病例中，检测到可能源自医院的 RVI，包括流感等“严重病毒”。我们的研究表明，自体造血干细胞移植患者的感染预防措施可以得到改善。
AdV：腺病毒；ALL：急性淋巴细胞白血病；AML：急性髓细胞白血病；auto-SCT：自体造血干细胞移植；hCoV：人冠状病毒；HD：霍奇金淋巴瘤；hMPV：人偏肺病毒；HRV：人鼻病毒；HSCT：异基因造血干细胞移植；IQR：四分位间距；GCT：生殖细胞肿瘤；MM：多发性骨髓瘤；NHL：非霍奇金淋巴瘤；PIV：副流感病毒；RSV：呼吸道合胞病毒。
