维生素D水平与子痫前期的关联。

Association of vitamin D levels with preeclampsia.

作者信息

Shahid Sana, Ladak Asma, Fatima Syeda Sadia, Zaidi Fatima Abid, Farhat Sabah

机构信息

Sir Syed Medical College, Karachi, Pakistan.

3rd Year Medical Student, Medical College, Aga Khan University, Karachi, Pakistan.

出版信息

J Pak Med Assoc. 2020 Dec;70(12(B)):2390-2393. doi: 10.47391/JPMA.414.

DOI:10.47391/JPMA.414

PMID:33475549

Abstract

OBJECTIVE

This study was aimed to assess maternal vitamin D status during pregnancy and determine the association between maternal 25(OH) D levels with risk of preeclampsia (PE).

METHODS

A cross-sectional study was conducted with 172 pregnant women recruited from JPMC between January and December 2017 who were divided as normotensive (n=80) and pre eclamptic (n=92) groups. Blood pressure was recorded at 20 and 32 weeks of gestation. Five ml of blood sample was collected at 20 weeks of gestation to assess the vitamin D levels by commercially available ELISA assay.

RESULTS

PE group had a significantly higher systolic (p<0.001) and diastolic (p<0.001) blood pressure at 20 weeks of gestation. Vitamin D levels were reported to be significantly lower (p<0.001) in the PE group (17.97±9.38 ng/ml) as compared to normotensive group (42.18±25.17 ng/ml). A strong negative correlation of Vitamin D levels with systolic blood pressure (r=-0.428; p<0.001) and diastolic blood pressure (r= 0.375; p<0.001) was found.

CONCLUSIONS

This study found a strong relationship between low vitamin D levels and pre-eclamptic manifestation.

摘要

目的

本研究旨在评估孕期母亲的维生素D状况，并确定母亲25(OH)D水平与先兆子痫（PE）风险之间的关联。

方法

进行了一项横断面研究，从2017年1月至12月在卡拉奇真纳大学医院（JPMC）招募了172名孕妇，她们被分为血压正常组（n = 80）和先兆子痫组（n = 92）。在妊娠20周和32周时记录血压。在妊娠20周时采集5毫升血样，通过市售酶联免疫吸附测定（ELISA）法评估维生素D水平。

结果

先兆子痫组在妊娠20周时收缩压（p<0.001）和舒张压（p<0.001）显著更高。据报告，先兆子痫组的维生素D水平（17.97±9.38纳克/毫升）与血压正常组（42.18±25.17纳克/毫升）相比显著更低（p<0.001）。发现维生素D水平与收缩压（r = -0.428；p<0.001）和舒张压（r = 0.375；p<0.001）呈强负相关。