Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Dig Dis Sci. 2021 Dec;66(12):4120-4127. doi: 10.1007/s10620-020-06814-1. Epub 2021 Jan 21.
Prescribing the right medication, at the right dose, to the right patient is the goal of every physician. Pharmacogenomic information is an emerging tool that can be used to deliver precision medicine. In this review, we discuss the pharmacogenomics of available PPIs, racial differences of CYP2C19 and how PPI pharmacogenomics affects the treatment of common gastrointestinal diseases. We also provide practical guidance on when to order pharmacogenomic testing, which test to order, and how to modify treatment based on published guidelines.
为合适的患者开具合适剂量的正确药物是每位医生的目标。药物基因组学信息是一种新兴工具，可用于提供精准医疗。在这篇综述中，我们讨论了现有质子泵抑制剂的药物基因组学、CYP2C19 的种族差异，以及 PPI 药物基因组学如何影响常见胃肠道疾病的治疗。我们还就何时进行药物基因组学检测、检测哪种测试以及如何根据已发表的指南修改治疗方案提供了实用指导。
