Kaneva Anastasiya M, Bojko Evgeny R
Institute of Physiology of Коmi Science Centre of the Ural Branch of the Russian Academy of Sciences, FRC Komi SC UB RAS, Syktyvkar, Russia.
Arch Physiol Biochem. 2023 Jun;129(3):682-689. doi: 10.1080/13813455.2020.1861027. Epub 2021 Jan 21.
Hypertension and obesity often coexist. There are sex differences in the mechanisms of obesity-related hypertension but the reasons for these differences are still not fully understood.
The aim of this study was to investigate sex differences in the development of hypertension associated with obesity.
A total of 866 men and 1022 women were selected for the study. Anthropometric measurements, including arterial pressure measurements, were performed. The plasma lipid levels were measured using an enzymatic method with commercially available kits.
In both overweight and obesity, hypertensive women had more atherogenic lipid profiles and higher values of lipid accumulation product (LAP) than normotensive women. In overweight and obese men, no significant differences in lipid levels or LAP were noted between the normotensive and hypertensive groups.
The pathogenesis of obesity-related hypertension in women differs from that in men and tends to be associated with metabolic disorders.
高血压和肥胖常常并存。肥胖相关高血压的发病机制存在性别差异，但这些差异的原因仍未完全明确。
本研究旨在探讨肥胖相关高血压发生发展过程中的性别差异。
共选取866名男性和1022名女性参与本研究。进行了人体测量，包括动脉压测量。采用酶法和市售试剂盒测量血浆脂质水平。
在超重和肥胖人群中，高血压女性比血压正常女性具有更多致动脉粥样硬化的血脂谱和更高的脂质蓄积产物（LAP）值。在超重和肥胖男性中，血压正常组和高血压组之间的血脂水平或LAP无显著差异。
女性肥胖相关高血压的发病机制与男性不同，且往往与代谢紊乱有关。
