Peng Li, Zhong Li-Li, Huang Zhen, Li Yan, Zhang Bing
Hunan Provincial Key Laboratory of Pediatric Respirology, Pediatric Medical Center, Hunan Provincial People's Hospital, Changsha 410005, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2021 Jan;23(1):74-77. doi: 10.7499/j.issn.1008-8830.2009012.
To study the clinical features of children with pneumonia (MPP) and peripheral lymphocytopenia.
A total of 310 MPP children who were hospitalized and underwent bronchoalveolar lavage from June 2018 to June 2019 were enrolled and divided into two groups: simple MPP group with 241 children (without peripheral lymphocytopenia) and MPP + peripheral lymphocytopenia group with 69 children. The two groups were compared in terms of clinical data and treatment outcome.
Compared with the simple MPP group, the MPP + peripheral lymphocytopenia group had significantly longer duration of fever and length of hospital stay and significant increases in C-reactive protein, lactate dehydrogenase, and DNA copies in bronchoalveolar lavage fluid ( < 0.05). Compared with the simple MPP group, the MPP + peripheral lymphocytopenia group had significantly higher incidence rates of intrapulmonary consolidation, extrapulmonary complications, and serious lesions under bronchoscopy (erosion or sputum bolt) and a significantly higher proportion of patients with severe MPP ( < 0.05).
Children with MPP and peripheral lymphocytopenia tend to have more severe immunologic injury. Peripheral blood lymphocyte count may be used to evaluate the severity of MPP.
研究肺炎支原体肺炎（MPP）合并外周血淋巴细胞减少患儿的临床特征。
选取2018年6月至2019年6月期间住院并行支气管肺泡灌洗的310例MPP患儿，分为两组：单纯MPP组241例（无外周血淋巴细胞减少）和MPP+外周血淋巴细胞减少组69例。比较两组的临床资料及治疗转归。
与单纯MPP组相比，MPP+外周血淋巴细胞减少组发热持续时间、住院时间显著延长，支气管肺泡灌洗液中C反应蛋白、乳酸脱氢酶、DNA拷贝数显著升高（P<0.05）。与单纯MPP组相比，MPP+外周血淋巴细胞减少组肺内实变、肺外并发症及支气管镜下严重病变（糜烂或痰栓）的发生率显著更高，重症MPP患者比例显著更高（P<0.05）。
MPP合并外周血淋巴细胞减少的患儿往往存在更严重的免疫损伤。外周血淋巴细胞计数可用于评估MPP的严重程度。
