核受体SUMO化修饰的功能。

Functions of nuclear receptors SUMOylation.

作者信息

Liu Wenhui, Zeng Min, Fu Nian

机构信息

Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China; Liver Disease Laboratory, Clinical Research Institute, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China.

出版信息

Clin Chim Acta. 2021 May;516:27-33. doi: 10.1016/j.cca.2021.01.007. Epub 2021 Jan 18.

DOI:10.1016/j.cca.2021.01.007

PMID:33476589

Abstract

The nuclear receptor superfamily is a family of ligand-activated transcription factors that play a key role in cell metabolism and human diseases. They can be modified after translation, such as acetylation, ubiquitination, phosphorylation and SUMOylation. Crosstalk between SUMO and ubiquitin, phosphorylation and acetylation regulates a variety of metabolic and physiological activities. Nuclear receptors play an important role in lipid metabolism, inflammation, bile acid homeostasis and autophagy. SUMOylation nuclear receptors can regulate their function and affect cell metabolism. It also provides a potential therapeutic target for atherosclerosis, tumor and other metabolic and inflammation-related diseases. This review focuses on the function of SUMOylation nuclear receptors.

摘要

核受体超家族是一类配体激活的转录因子家族，在细胞代谢和人类疾病中起关键作用。它们在翻译后可被修饰，如乙酰化、泛素化、磷酸化和小泛素样修饰（SUMOylation）。SUMO与泛素、磷酸化和乙酰化之间的相互作用调节多种代谢和生理活动。核受体在脂质代谢、炎症、胆汁酸稳态和自噬中起重要作用。SUMO化核受体可调节其功能并影响细胞代谢。它还为动脉粥样硬化、肿瘤及其他代谢和炎症相关疾病提供了潜在的治疗靶点。本综述聚焦于SUMO化核受体的功能。