National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, No.35, Keyan Road, Zhunan, Miaoli 350, Taiwan.
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, No.161, Section 6, Min Chuan East Road, Neihu, Taipei 114, Taiwan.
Int J Mol Sci. 2020 May 1;21(9):3207. doi: 10.3390/ijms21093207.
Defects in mucosal immune balance can lead to colonic diseases such as inflammatory bowel diseases and colorectal cancer. With the advancement of understanding for the immunological and molecular basis of colonic disease, therapies targeting transcription factors have become a potential approach for the treatment of colonic disease. To date, the biomedical significance of unique post-translational modifications on transcription factors has been identified, including phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. This review focuses on our current understanding and the emerging evidence of how post-translational regulations modify transcription factors involved in the etiology and pathophysiology of colonic disease as well as the implications of these findings for new therapeutic approaches in these disorders.
黏膜免疫平衡缺陷可导致结直肠疾病，如炎症性肠病和结直肠癌。随着对结直肠疾病免疫和分子基础的深入了解，针对转录因子的治疗方法已成为治疗结直肠疾病的一种潜在方法。迄今为止，已确定转录因子的独特翻译后修饰在生物医学上具有重要意义，包括磷酸化、甲基化、乙酰化、泛素化、SUMO 化和 O-GlcNAc 化。本综述重点介绍了我们目前对转录因子翻译后修饰如何参与结直肠疾病的病因和病理生理学的理解和新的证据，以及这些发现对这些疾病新治疗方法的意义。
