Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453002, China; Department of Psychology, Xinxiang Medical University, Henan, 453003, China.
Department of Psychology, Xinxiang Medical University, Henan, 453003, China.
Behav Brain Res. 2021 Apr 9;403:113135. doi: 10.1016/j.bbr.2021.113135. Epub 2021 Jan 18.
In recent years, more and more studies on disgust have shown the association between disgust and various psychopathologies. Revealing the spontaneous brain activity patterns associated with disgust sensitivity from the perspective of individual differences will give us an insight into the neurologic nature of disgust and its psychopathological vulnerability. Here, we used two modal brain imaging techniques (resting fMRI and resting EEG) to reveal spontaneous brain activity patterns closely related to disgust sensitivity. The amplitude of low-frequency fluctuation results showed that disgust sensitivity is negatively correlated with the spontaneous activity of the right cerebellum crus II and positively correlated with the spontaneous activity of the right superior frontal cortex, which are inhibition-related brain regions. Furthermore, the microstate results of rest EEG indicated that the corrected duration, occurrence rate, and contribution of Class C, which is related to the anterior default mode network and is considered to be related to subjective representation of one' own body by combining interoceptive information with affective salience, were significantly positively correlated with the disgust sensitivity level. This data-driven approach provides the first evidence on the intrinsic brain features of disgust sensitivity based on two resting-state brain modalities. The results represent an initial effort to uncover the neurological basis of disgust sensitivity and its connection to psychopathology.
近年来，越来越多的关于厌恶的研究表明，厌恶与各种精神病理学之间存在关联。从个体差异的角度揭示与厌恶敏感性相关的自发脑活动模式，将使我们深入了解厌恶的神经本质及其精神病理学易感性。在这里，我们使用了两种模态脑成像技术（静息 fMRI 和静息 EEG）来揭示与厌恶敏感性密切相关的自发脑活动模式。低频波动振幅结果表明，厌恶敏感性与右侧小脑 crus II 的自发活动呈负相关，与右侧额上皮质的自发活动呈正相关，这些区域与抑制有关。此外，静息 EEG 的微状态结果表明，与前默认模式网络相关的 C 类的校正持续时间、出现率和贡献，被认为是通过将内感受信息与情感显著性结合起来，对自身身体的主观表现进行组合，与厌恶敏感性水平呈显著正相关。这种基于两种静息态脑模态的基于数据的方法为厌恶敏感性的内在脑特征提供了第一个证据。这些结果代表了揭示厌恶敏感性的神经基础及其与精神病理学联系的初步努力。
