Child Health Department, Sultan Qaboos University Hospital, Infectious Diseases Unit, Alkoudh.123, Muscat, PO Box. 35, Oman.
Child Health Department, Royal Hospital, Infectious Diseases Unit, Al Ghubra area 111, Muscat PO Box 1331, Oman.
Int J Infect Dis. 2021 Mar;104:655-660. doi: 10.1016/j.ijid.2021.01.036. Epub 2021 Jan 18.
To describe the epidemiology, clinical and laboratory features, and outcome of children hospitalized with coronavirus disease 2019 (COVID-19) in the Middle East.
A multicenter retrospective study of children hospitalized with COVID-19 in 7 centers across Oman between February and July 2020.
In total, 56 children <14 years old required hospitalization in 7 Omani centers over 5 months (February - July 2020). Thirty-seven (68%) children were admitted with uncomplicated COVID-19, 13 (23%) with pneumonia and 5 (9%) with multisystem inflammatory syndrome in children. Infants constituted 41% of cases (23/56), approximately half of whom (12/23, 52%) were <2-months old. Fever was the most common symptom (46, 82%), followed by respiratory symptoms (33, 59%), and gastrointestinal symptoms (31, 55%). Twenty-two (39%) children had underlying medical conditions: sickle cell disease (7, 13%), chronic respiratory disease (4, 7%) and severe neurological impairment (4, 7%). Leukocytosis, elevated inflammatory markers and anemia were independently associated with intensive care admission. There were no mortalities related to admission with COVID-19 in this cohort.
Most of the children hospitalized with COVID-19 had a mild course and a satisfactory outcome. Sickle cell disease is the most common comorbidity associated with pediatric admission of COVID-19 in Oman.
描述中东地区儿童感染 2019 年冠状病毒病（COVID-19）的流行病学、临床和实验室特征及结局。
这是一项在 2020 年 2 月至 7 月期间在阿曼 7 家中心进行的儿童 COVID-19 多中心回顾性研究。
在 5 个月（2020 年 2 月至 7 月）期间，阿曼的 7 家中心共收治了 56 名<14 岁的 COVID-19 住院患儿。37 名（68%）患儿患有单纯性 COVID-19，13 名（23%）患有肺炎，5 名（9%）患有儿童多系统炎症综合征。婴儿占病例的 41%（23/56），其中约一半（12/23，52%）<2 个月大。发热是最常见的症状（46 例，82%），其次是呼吸道症状（33 例，59%）和胃肠道症状（31 例，55%）。22 名（39%）患儿存在基础疾病：镰状细胞病（7 例，13%）、慢性呼吸道疾病（4 例，7%）和严重神经功能障碍（4 例，7%）。白细胞增多、炎症标志物升高和贫血与入住重症监护病房独立相关。本队列中无因 COVID-19 住院而死亡的病例。
大多数因 COVID-19 住院的儿童病情较轻，结局良好。镰状细胞病是与阿曼儿童 COVID-19 住院相关的最常见合并症。
