线粒体钙信号在调控癌细胞命运的线粒体质量控制中的复杂作用。
Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate.
机构信息
Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology, Rourkela 769008, Odisha, India.
PG Department of Botany, Berhampur University, Berhampur 760007, India.
出版信息
Mitochondrion. 2021 Mar;57:230-240. doi: 10.1016/j.mito.2021.01.002. Epub 2021 Jan 18.
Mitochondrial quality control is crucial for sustaining cellular maintenance. Mitochondrial Ca plays an important role in the maintenance of mitochondrial quality control through regulation of mitochondrial dynamics, mitophagy and mitochondrial biogenesis for preserving cellular homeostasis. The regulation of this dynamic interlink between these mitochondrial networks and mitochondrial Ca appears indispensable for the adaptation of cells under external stimuli. Moreover, dysregulation of mitochondrial Ca divulges impaired mitochondrial control that results in several pathological conditions such as cancer. Hence this review untangles the interplay between mitochondrial Ca and quality control that govern mitochondrial health and mitochondrial coordinates in the development of cancer.
线粒体质量控制对于维持细胞的正常功能至关重要。线粒体 Ca 通过调节线粒体动力学、线粒体自噬和线粒体生物发生来维持线粒体质量控制，从而维持细胞内环境的稳定。这种线粒体网络和线粒体 Ca 之间的动态联系的调节对于细胞对外界刺激的适应是必不可少的。此外，线粒体 Ca 的失调会导致线粒体控制受损，从而导致多种病理状况，如癌症。因此，本综述阐述了线粒体 Ca 与质量控制之间的相互作用，这些作用控制着线粒体的健康和癌症发展中的线粒体协调。
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