Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166079. doi: 10.1016/j.bbadis.2021.166079. Epub 2021 Jan 19.
Transport proteins are essential for cells in allowing the exchange of substances between cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids modulate the function of transmembrane proteins such as transporters in two ways: Lipids are tightly and specifically bound to transport proteins and in addition they modulate from the bulk of the lipid bilayer the function of transport proteins. This overview summarizes currently available information at the ultrastructural level on lipids tightly bound to transport proteins and the impact of altered bulk membrane lipid composition. Human diseases leading to altered lipid homeostasis will lead to altered membrane lipid composition, which in turn affect the function of transporter proteins.
转运蛋白对于细胞在允许物质在细胞与其环境之间交换方面是必不可少的，这些物质通过形成紧密屏障的脂双层进行交换。膜脂以两种方式调节跨膜蛋白（如转运蛋白）的功能：脂类与转运蛋白紧密且特异性结合，并且它们从脂双层的大部分调节转运蛋白的功能。这篇综述总结了目前在超微结构水平上关于与转运蛋白紧密结合的脂类以及改变的总体膜脂组成的信息，以及改变的总体膜脂组成对转运蛋白功能的影响。导致脂质稳态改变的人类疾病将导致膜脂组成改变，进而影响转运蛋白的功能。
