Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Int J Pediatr Otorhinolaryngol. 2021 Mar;142:110630. doi: 10.1016/j.ijporl.2021.110630. Epub 2021 Jan 16.
Children with Down syndrome (DS) who have Laryngomalacia represent a specific management challenge due to their inherent multiple levels of airway obstruction and hypotonia. Therefore, the purpose of this study is to determine the outcome of supraglottoplasty (SGP) in children with DS.
A systematic review was performed following the PRISMA guideline. Data were collected from online medical databases- CINAHL, Cochrane Library, Google Scholar, Ovid MEDLINE, Ovid MEDLINE in process, PubMed, and Scopus.
all publications that address the outcome of supraglottoplasty in children who are less than 18 years old with Down syndrome prior to December 2018 were collected. The data were collected on different phases: Screening review using search words and controlled vocabularies during the period of November-December 2018, followed by a detailed review of screened articles based on inclusion and exclusion criteria, then a full review that included screening the references of selected articles.
Nine articles were included in the qualitative analysis. These articles included 231 subjects, out of which 32 children with DS met the inclusion criteria. Twenty patients (62.5%) were considered successfully treated and 12/32 failed including 1/32 (3.1%) mortality in the postoperative period. The duration of follow-up was 12-102 days. All of the patients whose treatment failed had significant comorbidities.
Although the success of SPG in children with DS is less than in otherwise healthy children, it remains an option especially in patients without comorbidities. Preoperative counseling of the families and thorough assessment are necessary to determine candidacy for SPG in children with DS.
患有唐氏综合征（DS）的儿童由于存在多个气道阻塞和低张力水平，因此在患有喉软骨软化症的情况下代表着特定的管理挑战。因此，本研究的目的是确定 DS 儿童行杓状软骨成形术（SGP）的结果。
根据 PRISMA 指南进行了系统评价。数据来自在线医学数据库-CINAHL、Cochrane 图书馆、Google Scholar、Ovid MEDLINE、Ovid MEDLINE 处理中、PubMed 和 Scopus。
收集了截至 2018 年 12 月以前所有针对 18 岁以下患有 DS 的儿童 SGP 结果的出版物。这些数据是在不同阶段收集的：使用搜索词和受控词汇在 2018 年 11 月至 12 月期间进行筛选审查，然后根据纳入和排除标准对筛选出的文章进行详细审查，然后进行包括筛选所选文章的参考文献在内的全面审查。
有 9 篇文章被纳入定性分析。这些文章包括 231 名受试者，其中 32 名 DS 儿童符合纳入标准。20 名患者（62.5％）被认为治疗成功，32 名中有 12 名（37.5％）治疗失败，包括 1 例（3.1％）在术后死亡。随访时间为 12-102 天。所有治疗失败的患者均有严重的合并症。
尽管 SGP 在 DS 儿童中的成功率低于其他健康儿童，但它仍然是一种选择，特别是在没有合并症的患者中。在对 DS 儿童进行 SPG 之前，需要对家属进行术前咨询并进行彻底评估，以确定其是否适合进行 SPG。
