Balseiro J, Fahey F H, Ziessman H A, Le T V
Division of Nuclear Medicine, Georgetown University Hospital, Washington, DC 20007.
Radiology. 1988 Apr;167(1):151-3. doi: 10.1148/radiology.167.1.3347717.
Dual-photon absorptiometry (DPA) was performed on both hips of 40 patients to determine if the calculated bone-mineral density (BMD) of one hip could be used to predict the BMD of the opposite hip. For the Ward triangle, femoral neck, and greater trochanter the correlation coefficients between the BMD of the two hips was .920, .917, and .843, and the standard errors (SE) of the estimate for the linear regression of the left hip on to the right were 0.067, 0.063, and 0.077 g cm-2. The absolute error of predicting one hip from the other was not a function of BMD and thus the relative error increases with lower BMD values. The relative errors were 17%, 8%, and 7% for BMDs of 0.4, 0.8, and 1.0 g cm-2, respectively. The interobserver variability was small, with an r value of .96 and an SE of the estimate value of 0.036 g cm-2. The relative error in the mild-to-moderate osteoporosis categories was 2.5 times the precision of the instrument, indicating that the asymmetry of BMD is due to real differences between hips. Therefore the BMD of one hip cannot be used to predict that of the other with sufficient accuracy to discriminate clinically relevant trends in BMD.
对40例患者的双侧髋部进行双能X线吸收法(DPA)检查,以确定一侧髋部计算得出的骨密度(BMD)是否可用于预测对侧髋部的骨密度。对于沃德三角区、股骨颈和大转子,两侧髋部骨密度的相关系数分别为0.920、0.917和0.843,左髋部对右髋部进行线性回归估计的标准误(SE)分别为0.067、0.063和0.077 g/cm²。根据一侧髋部预测另一侧髋部的绝对误差并非骨密度的函数,因此相对误差会随着骨密度值降低而增加。骨密度分别为0.4、0.8和1.0 g/cm²时,相对误差分别为17%、8%和7%。观察者间的变异性较小,r值为0.96,估计值的标准误为0.036 g/cm²。轻度至中度骨质疏松类别中的相对误差是仪器精度的2.5倍,这表明骨密度的不对称是由于两侧髋部之间的实际差异所致。因此,一侧髋部的骨密度不能用于以足够的准确度预测另一侧髋部的骨密度,从而无法区分临床上相关的骨密度变化趋势。