Marcarelli Marco, Zappia Marcello, Rissolio Lorenzo, Baroni Chiara, Astarita Carlo, Trovato Letizia, Graziano Antonio
Unit of Orthopedics and Traumatology of Chieri and Moncalieri, Santa Croce Hospital, 10024 Turin, Italy.
Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
J Clin Med. 2021 Jan 17;10(2):322. doi: 10.3390/jcm10020322.
(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondropathy. (2) Methods: Eight patients affected by knee chondropathy were evaluated before and after 6 months and 3 years following autologous cartilage micrografts by magnetic resonance imaging (MRI) for cartilage measurement and clinical assessment. (3) Results: All patients recovered daily activities, reporting pain reduction without the need for analgesic therapy; Oxford Knee Score (OKS) was 28.4 ± 6 and 40.8 ± 6.2 and visual analogue scale (VAS) was 5.5 ± 1.6 and 1.8 ± 0.7 before and after 6 months following treatment, respectively. Both scores remained stable after 3 years. Lastly, a significant improvement of the cartilage thickness was observed using MRI after 3 years. (4) Conclusions: Autologous cartilage micrografts can promote the formation of new cartilage, and could be a valid approach for the treatment of knee chondropathy.
（1）背景：膝关节局灶性软骨缺损会显著损害患者的生活质量。尽管有多种治疗选择，但尚无定论且存在若干局限性。本研究的目的是评估自体软骨微移植在膝关节软骨病治疗中的作用。（2）方法：对8例膝关节软骨病患者在自体软骨微移植术前、术后6个月及3年进行磁共振成像（MRI）检查，以测量软骨并进行临床评估。（3）结果：所有患者均恢复了日常活动，报告疼痛减轻，无需止痛治疗；治疗后6个月时，牛津膝关节评分（OKS）分别为28.4±6和40.8±6.2，视觉模拟评分（VAS）分别为5.5±1.6和1.8±0.7。3年后，这两个评分均保持稳定。最后，3年后通过MRI观察到软骨厚度有显著改善。（4）结论：自体软骨微移植可促进新软骨形成，可能是治疗膝关节软骨病的一种有效方法。
