Department of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia.
Department of Orthopaedic Surgery, University Hospital Sveti Duh, 10000 Zagreb, Croatia.
Cells. 2021 Sep 21;10(9):2496. doi: 10.3390/cells10092496.
Cell-based therapy represents a promising treatment strategy for cartilage defects. Alone or in combination with scaffolds/biological signals, these strategies open many new avenues for cartilage tissue engineering. However, the choice of the optimal cell source is not that straightforward. Currently, various types of differentiated cells (articular and nasal chondrocytes) and stem cells (mesenchymal stem cells, induced pluripotent stem cells) are being researched to objectively assess their merits and disadvantages with respect to the ability to repair damaged articular cartilage. In this paper, we focus on the different cell types used in cartilage treatment, first from a biological scientist's perspective and then from a clinician's standpoint. We compare and analyze the advantages and disadvantages of these cell types and offer a potential outlook for future research and clinical application.
细胞治疗为软骨缺损的治疗提供了一种很有前途的策略。这些策略与支架/生物信号联合或单独使用，为软骨组织工程开辟了许多新途径。然而，选择最佳的细胞来源并非易事。目前，正在研究各种类型的分化细胞（关节和鼻软骨细胞）和干细胞（间充质干细胞、诱导多能干细胞），以客观评估它们在修复受损关节软骨方面的优缺点。在本文中，我们重点介绍了用于软骨治疗的不同细胞类型，首先从生物科学家的角度，然后从临床医生的角度进行比较和分析。我们比较和分析了这些细胞类型的优缺点，并为未来的研究和临床应用提供了潜在的展望。
