Suo Rei, Kashitani Maho, Oyama Hikaru, Adachi Masaatsu, Nakahigashi Ryota, Sakakibara Ryo, Nishikawa Toshio, Sugita Haruo, Itoi Shiro
Department of Marine Science and Resources, Nihon University, Fujisawa, Kanagawa 252-0880, Japan.
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Mar Drugs. 2021 Jan 18;19(1):40. doi: 10.3390/md19010040.
Several polyclad flatworm species are known to contain high levels of tetrodotoxin (TTX), but currently TTX-bearing flatworms seem to be restricted to specific lineages belonging to the suborder Acotylea. During our ongoing study of flatworm toxins, high concentrations of TTXs were detected for the first time in the flatworm , suborder Cotylea, from the coastal area of Hayama, Kanagawa, Japan. Toxin levels were investigated by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), revealing that this species contains comparable concentrations of toxins as seen in planocerid flatworms such as . This finding indicated that there may be other species with significant levels of TTXs. The distribution of TTXs among other flatworm species is thus of great interest.
已知几种多肠扁虫含有高浓度的河豚毒素（TTX），但目前携带TTX的扁虫似乎仅限于无肠亚目的特定谱系。在我们正在进行的扁虫毒素研究中，首次在来自日本神奈川县叶山沿海地区的有肠亚目扁虫中检测到高浓度的TTX。通过高效液相色谱 - 串联质谱法（LC-MS/MS）研究毒素水平，结果表明该物种所含毒素浓度与诸如涡虫等涡虫纲扁虫相当。这一发现表明可能还有其他物种含有高浓度的TTX。因此，TTX在其他扁虫物种中的分布情况备受关注。
