Diabetes and Metabolic Diseases, Division of Internal Medicine, Department of Endocrinology, University Medical Centre Ljubljana, Zaloška Cesta 7, 1000 Ljubljana, Slovenia.
Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Zaloška Cesta 7, 1000 Ljubljana, Slovenia.
Int J Mol Sci. 2021 Jan 18;22(2):902. doi: 10.3390/ijms22020902.
Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.
临床前研究为胰高血糖素样肽 1（GLP-1）在味觉感知中的作用提供了一些重要的见解。这篇综述探讨了文献，以揭示 GLP-1 和味觉编码之间的一些分子机制和联系。味觉感受器细胞中的局部 GLP-1 产生、相邻神经上 GLP-1 受体的表达、从肠道到舌头的甜味化学物质感知中的功能连续性以及外周和中枢味觉编码中 GLP-1 诱导的信号通路的鉴定都强烈表明 GLP-1 参与了味觉感知，特别是甜味。然而，基于 GLP-1 的治疗对人类味觉编码的影响在很大程度上尚未得到解决。基于分子背景，我们鼓励在临床研究中进一步探索舌头作为 GLP-1 受体激动剂的新治疗靶点。鉴于味觉编码的药理学操作可能代表对抗肥胖和糖尿病的一种新的潜在策略，这个话题具有非常重要的临床意义。
