味蕾中胰高血糖素样肽-1信号对味觉敏感性的调节。
Modulation of taste sensitivity by GLP-1 signaling in taste buds.
作者信息
Martin Bronwen, Dotson Cedrick D, Shin Yu-Kyong, Ji Sunggoan, Drucker Daniel J, Maudsley Stuart, Munger Steven D
机构信息
National Institute on Aging/NIH, Baltimore, Maryland, USA.
出版信息
Ann N Y Acad Sci. 2009 Jul;1170:98-101. doi: 10.1111/j.1749-6632.2009.03920.x.
Abstract
Modulation of sensory function can help animals adjust to a changing external and internal environment. Even so, mechanisms for modulating taste sensitivity are poorly understood. Using immunohistochemical, biochemical, and behavioral approaches, we found that the peptide hormone glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) are expressed in mammalian taste buds. Furthermore, we found that GLP-1 signaling plays an important role in the modulation of taste sensitivity: GLP-1R knockout mice exhibit a dramatic reduction in sweet taste sensitivity as well as an enhanced sensitivity to umami-tasting stimuli. Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals.
摘要
感觉功能的调节有助于动物适应不断变化的外部和内部环境。即便如此，调节味觉敏感性的机制仍知之甚少。我们运用免疫组织化学、生物化学和行为学方法，发现肽激素胰高血糖素样肽-1（GLP-1）及其受体（GLP-1R）在哺乳动物味蕾中表达。此外，我们发现GLP-1信号传导在味觉敏感性调节中发挥重要作用：GLP-1R基因敲除小鼠的甜味敏感性显著降低，同时对鲜味刺激的敏感性增强。这些发现共同表明了一种新的旁分泌机制，用于哺乳动物味觉功能的激素调节。
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