Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Nutrients. 2021 Jan 18;13(1):264. doi: 10.3390/nu13010264.
In an aging society, preventing dysfunction and restoring function of the locomotive organs are necessary for long-term quality of life. Few interventional studies have investigated supplementation for locomotive syndrome. Additionally, very few interventional clinical studies on locomotive syndrome have been performed as placebo-controlled, randomized, double-blind studies. We previously found that the administration of 30% ethanolic extract of improved walking ability in a cast-immobilized skeletal muscle atrophy mouse model. Therefore, we conducted a clinical study to evaluate the effects of (CT) extract on the locomotive syndrome. Twenty-six subjects with pre-symptomatic or mild locomotive syndrome completed all tests and were analyzed in the study. Analyses of muscle mass and physical activity were performed based on the full analysis set. Intake of CT extract for 12 weeks increased step width (two-step test) and gait speed (5 m walking test) in patients over 60 years old compared with those in a placebo control ( = 0.046). In contrast, the skeletal muscle mass of the body trunk and limbs was unchanged following administration of CT extract. Adverse effects were evaluated by blood tests; no obvious adverse events were observed following the intake of CT extract. In conclusion, this placebo-controlled, randomized, double-blind study demonstrated that treatment with CT extract significantly prevented a decline in walking ability without any notable adverse effects in patients with locomotive syndrome.
在老龄化社会中，预防运动器官的功能障碍和恢复其功能对于长期的生活质量是必要的。很少有干预性研究调查过对运动综合征的补充治疗。此外，很少有针对运动综合征的干预性临床研究作为安慰剂对照、随机、双盲研究进行。我们之前发现，给予 30%乙醇提取物可改善石膏固定性骨骼肌萎缩小鼠模型的步行能力。因此，我们进行了一项临床研究，以评估 CT 提取物对运动综合征的影响。26 名有运动综合征前期或轻度运动综合征的受试者完成了所有测试，并在研究中进行了分析。根据全分析集进行肌肉量和身体活动的分析。与安慰剂对照组相比，CT 提取物的摄入可使 60 岁以上患者的步宽（两步测试）和步态速度（5 米步行测试）增加（ = 0.046）。然而，CT 提取物给药后身体躯干和四肢的骨骼肌量没有变化。通过血液检查评估不良反应；摄入 CT 提取物后没有观察到明显的不良反应。总之，这项安慰剂对照、随机、双盲研究表明，CT 提取物治疗可显著预防运动综合征患者步行能力下降，且无明显不良反应。
