Aoki Kana, Sakuma Mayumi, Endo Naoto
Department of Rehabilitation, Niigata Nishikan Medical Center Hospital, 4368, Maki-Kou, Nishikan-Ku, Niigata City, Niigata, 953-0041, Japan; Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori Chuo-Ku, Niigata City, Niigata, 951-8510, Japan.
Department of Physical Therapy, Faculty of Medical Technology, Niigata University of Health and Welfare, 1398, Shimami-cho, Kita-ku, Niigata City, Niigata, 950-3198, Japan.
J Orthop Sci. 2018 Jul;23(4):682-687. doi: 10.1016/j.jos.2018.03.011. Epub 2018 Apr 26.
We investigated the impact of exercise and vitamin D supplementation on physical function and locomotor dysfunction in community-dwelling elderly individuals.
In total, 148 community-dwelling elderly individuals (aged ≥60 years) who were not taking osteoporosis medications participated in a 24-week intervention. The participants were randomly divided into an exercise group, vitamin D group, and exercise and vitamin D group. The participants and outcome-assessing staff were not blinded to group assignment. Exercise comprised three daily sets each of single-leg standing (1 min/leg/set) and squatting (5-6 repetitions/set); vitamin D supplementation was 1000 IU/day. Participants were contacted every 2 weeks to check on their condition and encourage continued participation. The primary outcome was lower limb muscle strength and mass; secondary outcomes were several physical function measurements, serum 25-hydroxyvitamin D levels, and results of a self-assessment questionnaire completed pre- and post-intervention.
We analyzed data from 45, 42, and 43 participants in the exercise, vitamin D, and exercise and vitamin D groups, respectively, who completed the intervention. Locomotive syndrome, which involves reduced mobility due to locomotive organ impairment, was diagnosed in 99 participants (76.2%). Many physical function measurements improved in all groups. Lower limb muscle mass increased significantly in all three groups, with no significant differences between the groups in the degree of change. The average serum 25-hydroxyvitamin D of all vitamin D-supplemented participants increased from 28.1 ng/ml to 47.3 ng/ml after vitamin D supplementation.
Both exercise and vitamin D supplementation independently improved physical function and increased muscle mass in community-dwelling elderly individuals. Moreover, the combination of exercise and vitamin D supplementation might further enhance these positive effects.
UMIN Clinical Trial, UMIN000028229.
我们研究了运动和补充维生素D对社区居住老年人身体功能及运动功能障碍的影响。
共有148名未服用骨质疏松症药物的社区居住老年人（年龄≥60岁）参与了一项为期24周的干预研究。参与者被随机分为运动组、维生素D组以及运动加维生素D组。参与者和负责结果评估的工作人员知晓分组情况。运动包括每天进行三组单腿站立（每组每条腿1分钟）和深蹲（每组5 - 6次重复）；维生素D补充剂量为每日1000国际单位。每2周与参与者联系一次，检查他们的状况并鼓励继续参与。主要结局是下肢肌肉力量和质量；次要结局包括多项身体功能测量指标、血清25 - 羟维生素D水平以及干预前后完成的一份自我评估问卷的结果。
我们分别分析了运动组、维生素D组和运动加维生素D组中完成干预的45名、42名和43名参与者的数据。99名参与者（76.2%）被诊断为患有运动机能综合征，即由于运动器官损伤导致活动能力下降。所有组的许多身体功能测量指标都有所改善。所有三组的下肢肌肉质量均显著增加，组间变化程度无显著差异。所有补充维生素D的参与者血清25 - 羟维生素D的平均值在补充维生素D后从28.1纳克/毫升升至47.3纳克/毫升。
运动和补充维生素D均可独立改善社区居住老年人的身体功能并增加肌肉质量。此外，运动与补充维生素D相结合可能会进一步增强这些积极效果。
UMIN临床试验，UMIN000028229。
