Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua Campo Alegre 687, 4169-007 Porto, Portugal.
Molecules. 2021 Jan 19;26(2):501. doi: 10.3390/molecules26020501.
Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many research articles and reviews compile information on this important family of compounds. In this overview, the most recent research papers and reviews from 2020 are organized and analyzed, and a discussion on these data is included. Multiple electronic databases were scanned, including SciFinder, Mendeley, and PubMed, the latter being the main source of information. Particular attention was paid to the potential of coumarins as an important scaffold in drug design, as well as fluorescent probes for decaging of prodrugs, metal detection, and diagnostic purposes. Herein we do an analysis of the trending topics related to coumarin and its derivatives in the broad field of drug discovery.
香豆素是一类具有广泛生物活性的天然存在的分子。其结构和物理化学特性使它们成为药物化学和化学生物学中的一个重要的优势骨架。许多研究论文和综述都汇集了关于这一重要化合物家族的信息。在本篇综述中，对 2020 年的最新研究论文和综述进行了整理和分析，并对这些数据进行了讨论。扫描了多个电子数据库，包括 SciFinder、Mendeley 和 PubMed，其中 PubMed 是主要的信息来源。特别关注了香豆素作为药物设计中重要骨架的潜力，以及作为前药去封闭、金属检测和诊断目的的荧光探针。本文对与香豆素及其衍生物在药物发现的广泛领域相关的热门话题进行了分析。
