Faculty of Arts and Sciences, Department of Biology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Biomarkers. 2021 May;26(3):248-259. doi: 10.1080/1354750X.2021.1878558. Epub 2021 Feb 3.
Accumulation of Gamma aluminium oxide nanoparticles γ-AlO NPs significant impact on aquatic ecosystems. However, the toxicity of γ-AlO NPs in aquatic organisms has been limited investigated. This study investigated histopathological changes and antioxidant responses induced by different concentrations of γ-AlO NPs in .
In this study, mussels were exposed to different concentrations of 5 nm γ-AlO NPs (0, 5, 20 and 40 mg/L) for 96 h under controlled laboratory conditions. Gill and digestive gland from mussels were assessed to histopathological (light microscopy, histopathological condition indices, digestive gland tubule types), SOD, CAT, GPx activities.
Histopathological indices calculated higher, and significantly different in all exposure groups compared to the control group in gill and digestive gland ( < 0.05). Atrophic phase tubules proportion very high in 20 and 40 mg/L γ-AlO NPs exposure groups. No significant changes in CAT activities in the gill and digestive gland ( > 0.05). Superoxide dismutase (SOD) activities significantly different ( ≤ 0.05) in the digestive gland from 20 mg/L γ-AlO NPs exposures, and GPx activities significantly different ( < 0.05) in gill from 40 mg/L γ-AlO NPs exposures.
These results indicate that contamination of γ-AlO NPs negatively affects the aquatic organism.
γ- 氧化铝纳米粒子（γ-AlO NPs）在水生生态系统中的积累对水生生态系统有重大影响。然而，γ-AlO NPs 对水生生物的毒性研究还很有限。本研究调查了不同浓度γ-AlO NPs 对贻贝的组织病理学变化和抗氧化反应。
在本研究中，贻贝在实验室控制条件下暴露于不同浓度的 5nmγ-AlO NPs（0、5、20 和 40mg/L）96 小时。贻贝的鳃和消化腺用于评估组织病理学（光镜、组织病理学状况指数、消化腺小管类型）、SOD、CAT、GPx 活性。
与对照组相比，所有暴露组的鳃和消化腺的组织病理学指数均较高且差异显著（P<0.05）。在 20 和 40mg/Lγ-AlO NPs 暴露组中，萎缩期小管的比例非常高。CAT 活性在鳃和消化腺中没有显著变化（P>0.05）。20mg/Lγ-AlO NPs 暴露组消化腺中超氧化物歧化酶（SOD）活性显著不同（P≤0.05），40mg/Lγ-AlO NPs 暴露组鳃中谷胱甘肽过氧化物酶（GPx）活性显著不同（P<0.05）。
这些结果表明，γ-AlO NPs 的污染对水生生物有负面影响。
