Department of Pediatrics, Department of Pediatrics and Prenatal Cardiology, University Hospital Ostrava, Ostrava, Czech Republic.
Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5253-5259. doi: 10.1080/14767058.2021.1876655. Epub 2021 Jan 21.
The first aim was to develop a nomogram for the area of the right atrium (ARA) of the fetal heart in uncomplicated singleton pregnancies. The second aim was to assess diagnostic indices of ARA to distinguish between tricuspid regurgitation (TR) with and without concomitant congenital heart defect (CDH).
The study was conducted between 2014 and 2019. Fetal echocardiography was performed on fetuses with and without TR. For the first aim, ARA was measured in 460 fetuses without proven structural and chromosomal abnormalities, and for the second aim, ARA was measured in 1077 fetuses with TR.
A nomogram for the ARA of fetuses with normal hearts was developed. TR was observed in 4.5% (1077/23,771) of euploid fetuses; 4.3% (1020/23,771) of fetuses had TR without a concomitant CHD, and 0.2% (57/23,771) fetuses had TR with a concomitant CHD. No significant differences in ARAs were found between fetuses with normal hearts without TR ( = 22,694) and fetuses with TR without CHD ( = 1020; = .751). Fetuses with TR and CHDs had different ARA than fetuses with normal hearts without TR and fetuses with TR without CHD ( < .0005 in both cases).
ARA seems to be an auxiliary marker to distinguish the presence of CHD in fetuses with TR.
一是为不伴有复杂先天性心脏病（CHD）的单胎妊娠胎儿右心房（RA）面积制定一个列线图。二是评估 RA 面积的诊断指标，以区分伴有和不伴有 CHD 的三尖瓣反流（TR）。
本研究于 2014 年至 2019 年进行。对伴有和不伴有 TR 的胎儿进行胎儿超声心动图检查。第一项研究中，在 460 例无结构和染色体异常的胎儿中测量 RA；第二项研究中，在 1077 例伴有 TR 的胎儿中测量 RA。
建立了正常心脏胎儿 RA 的列线图。在 23771 例正常胎儿中，发现 4.5%（1077 例）有 TR；4.3%（1020 例）无 CHD 的胎儿有 TR，0.2%（57 例）有 CHD 的胎儿有 TR。无 TR 的正常胎儿（ = 22694 例）和无 CHD 的 TR 胎儿（ = 1020 例）的 RA 无显著差异（ = .751）。伴有 CHD 的 TR 胎儿的 RA 与无 TR 的正常胎儿和无 CHD 的 TR 胎儿不同（两种情况均 <.0005）。
RA 似乎是区分伴有 TR 的胎儿 CHD 的一个辅助标志物。
