Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto 4050-313, Portugal.
Centro de Medicina Fetal, Medicina Fetal Porto, Serviço de Obstetrícia-Centro Materno Infantil do Norte, Porto 4099-001, Portugal.
Curr Cardiol Rev. 2023;19(3):e061222211643. doi: 10.2174/1573403X19666221206115642.
Tricuspid regurgitation is a cardiac valvular anomaly that consists of the return of blood to the right atrium during systole due to incomplete valve closure. This structure can be visualized on ultrasound between 11 and 14 weeks of gestation in most cases. Despite being a common finding, even in healthy fetuses, the presence of tricuspid regurgitation may be associated with chromosomal and structural abnormalities. The evaluation of tricuspid flow and the presence of regurgitation on first-trimester ultrasound has shown promising results regarding its role in the early detection of aneuploidies, congenital heart defects, and other adverse perinatal outcomes. This review article aims to demonstrate the importance of tricuspid regurgitation as a secondary marker, and consequently, significant benefits of its early detection when added to the combined first-trimester screening. Its value will be discussed, namely its sensitivity and specificity, alone and together with other current markers in the fetal assessment performed in the first-trimester ultrasound.
三尖瓣反流是一种心脏瓣膜异常，由于瓣膜关闭不完全，导致血液在收缩期回流到右心房。在大多数情况下，该结构可在妊娠 11 至 14 周的超声检查中看到。尽管三尖瓣反流在健康胎儿中很常见，但它的存在可能与染色体和结构异常有关。在早孕期超声检查中评估三尖瓣血流和反流情况，显示其在早期发现非整倍体、先天性心脏缺陷和其他不良围产期结局方面具有良好的效果。本文旨在强调三尖瓣反流作为次要标志物的重要性，以及在联合早孕期筛查中早期发现时带来的显著益处。本文将讨论其价值，包括其在单独和与其他当前标志物一起用于早孕期超声胎儿评估时的敏感性和特异性。
