CHU Réunion, Service des Maladies Infectieuses - Dermatologie, Saint Pierre, La Réunion, France.
CHU Réunion, Laboratoire de microbiologie, Saint Pierre, La Réunion, France.
BMC Infect Dis. 2021 Jan 21;21(1):95. doi: 10.1186/s12879-021-05801-9.
Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean region to determine whether current STI screening practices should be updated.
This cross-sectional study examined all patients who visited the STI clinic between 2014 and 2015. Triplex polymerase chain reaction screening for CT, NG, and MG was performed on urine, vaginal, pharyngeal, and anal specimens (FTD Urethritis Basic Kit, Fast Track Diagnostics, Luxembourg).
Of the 851 patients enrolled in the study, 367 were women (367/851, 43.2%) and 484 were men (484/851, 56.0%). Overall, 826 urogenital specimens (826/851, 97.1%), 606 pharyngeal specimens (606/851, 71.2%), and 127 anal specimens (127/851, 14.9%) were taken from enrolled patients. The prevalence of urogenital CT and MG was high in women ≤25 years (19/186, 10.21%; 5/186, 2.69%) and in men who have sex with women ≤30 years (16/212, 7.54%; 5/212, 2.36%). Among patients with urogenital CT infection, 13.7% (7/51) had urethritis. All patients with urogenital MG infection were asymptomatic. Men who have sex with men had a high prevalence of pharyngeal CT (2/45, 4.44%) and NG (3/44, 6.81%) and a high prevalence of anal CT (2/27, 7.41%), NG (2/27, 7.40%), and MG (1/27, 3.70%). After excluding patients with concomitant urogenital infection, extragenital infections with at least 1 of the 3 pathogens were found in 20 swabs (20/91, 21.9%) taken from 16 patients (16/81, 19.7%), all of them asymptomatic.
Routine multisite screening for CT, NG, and MG should be performed to mitigate the transmission of STIs in high-risk sexually active populations.
性传播感染（STI）筛查的建议在各国之间存在显著差异。本研究评估了在法属印度洋地区的一家性传播感染诊所就诊的患者中，沙眼衣原体（CT）、淋病奈瑟菌（NG）和生殖支原体（MG）引起的泌尿生殖道和生殖道外感染的流行率，以确定当前的 STI 筛查实践是否需要更新。
本横断面研究纳入了 2014 年至 2015 年间在该性传播感染诊所就诊的所有患者。对尿液、阴道、咽和肛门标本（FTD 尿道炎基础试剂盒，Fast Track Diagnostics，卢森堡）进行 CT、NG 和 MG 的三联聚合酶链反应筛查。
在纳入的 851 例患者中，367 例为女性（367/851，43.2%），484 例为男性（484/851，56.0%）。总体而言，从纳入的患者中采集了 826 份泌尿生殖道标本（826/851，97.1%）、606 份咽标本（606/851，71.2%）和 127 份肛门标本（127/851，14.9%）。≤25 岁的女性（19/186，10.21%；5/186，2.69%）和≤30 岁的女性与女性发生性行为的男性（16/212，7.54%；5/212，2.36%）中，泌尿生殖道 CT 和 MG 的流行率较高。在患有泌尿生殖道 CT 感染的患者中，13.7%（7/51）患有尿道炎。所有患有泌尿生殖道 MG 感染的患者均无症状。男男性行为者中，咽 CT（2/45，4.44%）和 NG（3/44，6.81%）以及肛 CT（2/27，7.41%）、NG（2/27，7.40%）和 MG（1/27，3.70%）的流行率较高。排除同时存在泌尿生殖道感染的患者后，在 16 例（16/81，19.7%）患者的 20 份标本（20/91，21.9%）中发现了至少一种 3 种病原体的生殖道外感染，所有患者均无症状。
应常规对 CT、NG 和 MG 进行多部位筛查，以减轻高危性行为人群中 STI 的传播。
