Liu Chao, Wang Kai, Zhang Min, Hu Xiaoyu, Hu Tian, Liu Yumei, Hu Qinyong, Wu Shikai, Yue Jinbo
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
NPJ Precis Oncol. 2021 Jan 21;5(1):1. doi: 10.1038/s41698-020-00139-y.
Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.
对于新冠病毒疾病（COVID-19）合并结直肠癌患者中血管紧张素转换酶2（ACE2）和跨膜丝氨酸蛋白酶2（TMPRSS2）的表达模式或COVID-19的临床特征了解甚少。我们在批量和单细胞RNA测序图谱中均发现，ACE2和TMPRSS2在肿瘤及正常结直肠上皮组织中高水平表达。在临床上，与单纯COVID-19患者相比，合并结直肠癌和COVID-19的患者更易出现淋巴细胞减少、呼吸频率加快以及超敏C反应蛋白水平升高。这些结果表明，结直肠癌患者可能对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染尤为易感。需要进一步的机制研究来支持我们的发现。
