Colorectal Cancer that Highly Express Both and , Suggesting Severe Symptoms to SARS-CoV-2 Infection.

The epidemic of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in the world pose a global health emergency. Cancer has been identified as a risk factor for the novel Coronavirus disease 2019 (COVID-19). The and have been implicated in SARS-CoV-2 infection for mediating viral entry into the host cell. However, a systematic analysis of aberrant expression of and was not yet reported in multiple human cancers. Here, we analyzed gene expression of and across 31 types of tumors. Notably, overexpression of and have been observed in colorectal cancer including colon adenocarcinoma (COAD), and rectum adenocarcinoma (READ). In addition, the colorectal tumors with upregulated gene expressing presented with decreased DNA methylation levels. DNA methylation might be one of the reasons for abnormal expression of and . Conclusively, colorectal cancer was the only cancer with the upregulated expression of and . More care of colorectal cancer patients is needed in multiple cancers affected by the COVID-19 outbreak.