De Letter Miet, Cocquyt Elissa-Marie, Cromheecke Oona, Criel Yana, De Cock Elien, De Herdt Veerle, Szmalec Arnaud, Duyck Wouter
Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Front Psychol. 2021 Jan 5;11:553970. doi: 10.3389/fpsyg.2020.553970. eCollection 2020.
Language-related potentials are increasingly used to objectify (mal)adaptive neuroplasticity in stroke-related aphasia recovery. Using preattentive [mismatch negativity (MMN)] and attentive (P300) phonologically related paradigms, neuroplasticity in sensory memory and cognitive functioning underlying phonological processing can be investigated. In aphasic patients, MMN amplitudes are generally reduced for speech sounds with a topographic source distribution in the right hemisphere. For P300 amplitudes and latencies, both normal and abnormal results have been reported. The current study investigates the preattentive and attentive phonological discrimination ability in 17 aphasic patients (6 monolinguals and 11 bilinguals, aged 41-71 years) at two timepoints during aphasia recovery. Between the two timepoints, a significant improvement of behavioral language performance in both languages is observed in all patients with the MMN latency at timepoint 1 as a predictive factor for aphasia recovery. In contrast to monolinguals, bilingual aphasic patients have a higher probability to improve their processing speed during rehabilitation, resulting in a shortening of the MMN latency over time, which sometimes progresses toward the normative values.
与语言相关的电位越来越多地被用于客观评估中风相关性失语恢复过程中的（不）适应性神经可塑性。利用前注意[失配负波（MMN）]和注意（P300）语音相关范式，可以研究语音处理背后的感觉记忆和认知功能中的神经可塑性。在失语症患者中，右半球具有地形源分布的语音的MMN波幅通常会降低。关于P300波幅和潜伏期，既有正常结果也有异常结果的报道。本研究调查了17名失语症患者（6名单语者和11名双语者，年龄41 - 71岁）在失语恢复过程中两个时间点的前注意和注意语音辨别能力。在这两个时间点之间，所有患者两种语言的行为语言表现均有显著改善，其中时间点1的MMN潜伏期是失语恢复的预测因素。与单语者不同，双语失语症患者在康复过程中提高处理速度的可能性更高，导致MMN潜伏期随时间缩短，有时会趋向于正常数值。
