Wong Antonio A W L, Lozada Jerome, Lepage Mathieu L, Zhang Chengcheng, Merkens Helen, Zeisler Jutta, Lin Kuo-Shyan, Bénard François, Perrin David M
Department of Chemistry , University of British Columbia (UBC) , 2036 Main Mall , Vancouver , BC , V6T 1Z1 Canada . Email:
Department of Molecular Oncology , B.C. Cancer Research Centre (BCCRC) , 675 West 10th Avenue , Vancouver , BC , V5Z 1L3 Canada.
RSC Med Chem. 2020 Apr 23;11(5):569-576. doi: 10.1039/d0md00054j. eCollection 2020 May 1.
In pursuit of F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C-AMBF and dT-N-AMBF, that are radiofluorinated by isotope exchange (IEX) and studied as PET imaging agents in mice with tumor xenografts. dT-C-AMBF shows preferential, and tumor-specific, uptake over dT-N-AMBF. This work provides a new synthetic method in order to access new nucleoside tracers for PET imaging.
为了寻找用于正电子发射断层扫描（PET）成像的F标记核苷，我们报道了两种胸苷（dT）类似物dT-C-AMBF和dT-N-AMBF的化学合成及放射化学合成，它们通过同位素交换（IEX）进行放射性氟化，并作为PET成像剂在荷瘤异种移植小鼠中进行研究。与dT-N-AMBF相比，dT-C-AMBF表现出优先且肿瘤特异性的摄取。这项工作提供了一种新的合成方法，以便获得用于PET成像的新核苷示踪剂。
