青少年慢性多关节炎中α-1-蛋白酶抑制剂MZ表型频率增加。
Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.
作者信息
Arnaud P, Galbraith R M, Faulk W P
出版信息
J Clin Invest. 1977 Dec;60(6):1442-4. doi: 10.1172/JCI108906.
Abstract
Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.
摘要
采用等电聚焦和印迹免疫固定法，对96名患幼年型慢性关节炎的英国儿童测定了α1-蛋白酶抑制剂的Pi表型。与地理位置匹配的对照人群（1.6%）相比，发现MZ表型的频率显著增加（10.41%）。本研究结果提示，α1-蛋白酶抑制剂的Z缺陷等位基因的存在可能是幼年型慢性关节炎关节损伤的一个易感、加重或持续因素。
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