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非裔人群与高加索人群的皮肤黑素瘤及其相关问题的对比研究。

Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians.

机构信息

Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.

出版信息

Dermatol Ther. 2021 Mar;34(2):e14790. doi: 10.1111/dth.14790. Epub 2021 Jan 25.

Abstract

Cutaneous melanoma is uncommon in people of African descent unlike their Caucasian counterparts. This rarity of cutaneous melanoma in people of African descent makes studies in this group difficult. In the few studies that are available, several differences exist in the incidence, disease severity, course of the disease, treatment modalities and survival rates between these two groups. Observed difference in cutaneous melanoma between people of African descent and Caucasians include; a higher incidence and better prognosis in Caucasians, a low awareness of melanoma, no definite risk factors, presentation with advanced disease, poor melanoma specific survival in people of African descent. Other differences are a better UV-induced DNA damage recovery, acral as opposed to truncal melanoma, female preponderance and lack of preventive measures in people of African descent.

摘要

与白种人相比,非裔人群中皮肤黑色素瘤较为少见。这种非裔人群中皮肤黑色素瘤的罕见性使得对该人群的研究变得困难。在为数不多的可用研究中,这两个群体在发病率、疾病严重程度、疾病进程、治疗方式和生存率方面存在着若干差异。在非裔人群和白种人之间观察到的皮肤黑色素瘤差异包括:白种人发病率更高,预后更好,对黑色素瘤的认识较低,没有明确的危险因素,疾病表现为晚期,非裔人群的黑色素瘤特异性生存率较差。其他差异还包括更好的紫外线诱导的 DNA 损伤恢复、肢端黑色素瘤而非躯干黑色素瘤、女性优势以及非裔人群缺乏预防措施。

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