Trinity College Institute of Neuroscience, School of Medicine, Trinity College Dublin, the University of Dublin, Dublin, Ireland.
University of Technology Sydney, Sydney, New South Wales, Australia.
Alzheimers Dement. 2021 Jun;17(6):1026-1041. doi: 10.1002/alz.12262. Epub 2021 Jan 21.
This review aims to systematically identify and appraise the methodological quality of claims on the cost of delirium; and discuss challenges and opportunities for improvements in the precision of the estimates.
Searches of scientific papers and gray literature were performed up until June 2020. The Larg and Moss checklist was used to assess the methodological quality of the included studies.
After deduplication, the search identified 317 potentially relevant articles, of which 17 articles were eligible for inclusion. After adjusting for inflation and common currency, the cost of delirium ranged between $806 and $24,509 (in 2019 US$).
This review found significant variation among the cost estimates and methodological quality. There has been limited focus on dementia as a sequela of delirium in terms of economic implications, but recent evidence suggests cost implications of delirium may be 52% higher when dementia is considered.
本综述旨在系统地识别和评估关于谵妄成本的主张的方法学质量，并讨论提高估计精度的挑战和机遇。
对科学文献和灰色文献进行了截至 2020 年 6 月的检索。采用 Larg 和 Moss 清单评估纳入研究的方法学质量。
在剔除重复项后，搜索共确定了 317 篇潜在相关文章，其中 17 篇文章符合纳入标准。经通胀和通用货币调整后，谵妄的成本范围在 806 美元至 24509 美元（2019 年的美元）之间。
本综述发现成本估计值和方法学质量存在显著差异。在痴呆症作为谵妄的后遗症的经济影响方面，关注有限，但最近的证据表明，考虑到痴呆症时，谵妄的成本影响可能高出 52%。
