Hoch Jonas, Müller Martin, Unger Inga, Mitzkat Anika, Denninger Natascha-Elisabeth
Department of Primary Care and Health Services Research, Nursing Science and Interprofessional Care, Heidelberg University Medical Faculty Heidelberg, Heidelberg, Germany
Heidelberg University Hospital Department of Internal Medicine, Heidelberg, Germany.
BMJ Open. 2025 Sep 15;15(9):e105801. doi: 10.1136/bmjopen-2025-105801.
Delirium is a critical and complex neuropsychiatric syndrome that significantly affects older adults in general hospital wards. Although multicomponent interventions have been shown to be effective in preventing delirium, the consistent implementation remains a challenge. Also, to manage the complex pathway of patients from admission to discharge in hospital, the involvement of the nursing staff is essential. Developing a nurse-led clinical pathway for delirium prevention could provide a structured approach to improving care quality. For intervention development taking account of the complexity of the clinical environment, the UK Medical Research Council framework is frequently used. A core element of this framework is mapping a programme theory that explains how, for whom and in what circumstances an intervention may work. The realist review methodology is well suited to uncovering the underlying mechanisms, contexts and outcomes of interventions, translating these into a programme theory.The aim of this realist review is to develop a programme theory for a nurse-led clinical pathway to prevent delirium in older adults aged 65 years or older in general hospital wards and to identify strategies to support its effective implementation.
The realist review is based on the methodical framework developed by Pawson and further adapted by Rycroft-Malone and the reporting will follow the Realist And MEta-narrative Evidence Syntheses: Evolving Standards guidelines. The process comprises four steps: (1) defining the review scope; (2) systematically searching for and appraising the evidence; (3) extracting and synthesising findings and (4) developing a narrative synthesis. Interest holders, including clinical and academic experts, will be actively involved as an expert reference group to inform and refine the programme theory. The final programme theory will be presented in Context-Mechanism-Outcome configurations and the Implementation Research Logic Model.
Since no data are collected as part of the review, ethical approval is not required. Findings will be disseminated through academic conferences and publication in a peer-reviewed journal.
This protocol has been registered at Open Science Framework (https://doi.org/10.17605/OSF.IO/7EPTF).
谵妄是一种严重且复杂的神经精神综合征,对综合医院病房中的老年人有显著影响。尽管多组分干预措施已被证明对预防谵妄有效,但持续实施仍是一项挑战。此外,为了管理患者从入院到出院的复杂流程,护理人员的参与至关重要。制定以护士为主导的谵妄预防临床路径可为提高护理质量提供一种结构化方法。考虑到临床环境的复杂性,在干预措施开发中常使用英国医学研究理事会框架。该框架的一个核心要素是绘制一个项目理论,解释一项干预措施对谁、在何种情况下以及如何发挥作用。现实主义综述方法非常适合揭示干预措施的潜在机制、背景和结果,并将其转化为项目理论。本现实主义综述的目的是为以护士为主导的临床路径制定一个项目理论,以预防综合医院病房中65岁及以上老年人的谵妄,并确定支持其有效实施的策略。
本现实主义综述基于Pawson开发并由Rycroft-Malone进一步改编的方法框架,报告将遵循《现实主义与元叙事证据综合:不断发展的标准》指南。该过程包括四个步骤:(1)确定综述范围;(2)系统搜索和评估证据;(3)提取和综合研究结果;(4)进行叙事性综合。包括临床和学术专家在内的利益相关者将作为专家参考小组积极参与,为项目理论提供信息并进行完善。最终的项目理论将以背景-机制-结果配置和实施研究逻辑模型呈现。
由于综述过程中不收集数据,因此无需伦理批准。研究结果将通过学术会议和在同行评审期刊上发表进行传播。
本方案已在开放科学框架(https://doi.org/10.17605/OSF.IO/7EPTF)注册。