Mueller-Eckhardt G, Giers G, Salama A, Schendel D J, Fass G, Mueller-Eckhardt C
Institute of Clinical Immunology and Blood Transfusion, University of Giessen, FRG.
Vox Sang. 1988;54(1):59-61. doi: 10.1111/j.1423-0410.1988.tb01615.x.
To evaluate a possible role of major-histocompatibility-complex (MHC)-related immune-response genes for the selective production of drug-induced antibodies, HLA class I (ABC), class II (DR, DQ), class III (BF, C2, C4A, C4B) as well as glyoxalase-1 allotypes were investigated in 26 patients with nomifensine-induced immune hemolytic anemia. No statistically significant deviations of MHC antigen frequencies were noted. The possible implications of these findings are discussed.
为评估主要组织相容性复合体（MHC）相关免疫反应基因在药物诱导抗体选择性产生中的可能作用，对26例诺米芬辛诱导的免疫性溶血性贫血患者的HLAⅠ类（ABC）、Ⅱ类（DR、DQ）、Ⅲ类（BF、C2、C4A、C4B）以及乙二醛酶-1同种异型进行了研究。未发现MHC抗原频率有统计学意义的偏差。讨论了这些发现的可能意义。
