Mueller-Eckhardt C, Allolio B, Salama A, Kiefel V, Deuss U
Transfusion. 1987 May-Jun;27(3):250-2. doi: 10.1046/j.1537-2995.1987.27387235632.x.
A 53-year-old white woman had severe hemolytic anemia while taking nomifensine. A drop of hemoglobin to 61 g per I prompted the transfusion of two units of packed red cells. Nine days later, severe thrombocytopenia with multiple petechiae ensued. Both hemolysis and thrombocytopenia resolved promptly upon withdrawal of the drug and short-term prednisolone treatment. Serologic studies showed nomifensine-dependent, metabolite-specific red cell antibodies as the cause of immune-mediated hemolysis and, in serum samples obtained after purpura, strong platelet-specific PlA1 and weak HLA antibodies suggested a diagnosis of posttransfusion purpura.
一名53岁的白人女性在服用诺米芬辛时出现了严重的溶血性贫血。血红蛋白降至每升61克促使输注了两单位浓缩红细胞。九天后，出现了伴有多处瘀点的严重血小板减少症。停用该药物并进行短期泼尼松龙治疗后，溶血和血小板减少症迅速缓解。血清学研究表明，诺米芬辛依赖性、代谢物特异性红细胞抗体是免疫介导溶血的原因，并且在紫癜后采集的血清样本中，强血小板特异性PlA1和弱HLA抗体提示诊断为输血后紫癜。
