Ríos Juvenal A, Barake M Francisca, Arce María José, López-Köstner Francisco, Labbe Tomas P, Villena Jessica, Becerra Sergio
Escuela de Medicina, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.
Centro de Envejecimiento y Regeneración UC, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Med Chil. 2020 Jun;148(6):858-867. doi: 10.4067/S0034-98872020000600858.
Colorectal (CRC) is one of the most common types of cancer worldwide. Most tumors develop from an adenoma in a period of 10 to 15 years, but some may appear without previous adenomatous lesions. Seventy-five percent of colorectal cancers are sporadic, 20% have a family component (first or second-degree relatives with CRC) and 5% have a hereditary predisposition with a Mendelian pattern. The epidemiological evolution in the recent years in Chile has a worrisome evolution and the treatment costs of advanced stages are a burden for the healthcare system. We herein highlight the main Chilean medical and scientific contributions on the pathogenesis, early diagnosis, and treatment of CRC, which lead to its better understanding, and therefore better management, based on local evidence.
结直肠癌(CRC)是全球最常见的癌症类型之一。大多数肿瘤在10至15年的时间里由腺瘤发展而来,但有些可能在没有先前腺瘤性病变的情况下出现。75%的结直肠癌是散发性的,20%有家族成分(一级或二级亲属患有结直肠癌),5%有孟德尔模式的遗传易感性。近年来智利的流行病学演变令人担忧,晚期阶段的治疗费用给医疗系统带来了负担。在此,我们重点介绍智利在结直肠癌发病机制、早期诊断和治疗方面的主要医学和科学贡献,这些贡献基于当地证据,有助于更好地理解结直肠癌,从而实现更好的管理。