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Intensifying Neoadjuvant Therapy for Rectal Cancers Towards Watchful Waiting.

作者信息

Chakrabarti Deep, Akhtar Naseem, Rajan Shiv, Qayoom Sumaira, Kumar Vijay, Chaturvedi Arun, Gupta Rajeev, Bhatt Madan Lal Brahma

机构信息

Department of Radiation Oncology, King George's Medical University, Lucknow, India.

Department of Surgical Oncology, King George's Medical University, Lucknow, India.

出版信息

Ann Surg Oncol. 2021 Jul;28(7):4062-4063. doi: 10.1245/s10434-020-09512-4. Epub 2021 Jan 22.

DOI:10.1245/s10434-020-09512-4
PMID:33481127
Abstract
摘要

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Intensifying Neoadjuvant Therapy for Rectal Cancers Towards Watchful Waiting.强化直肠癌新辅助治疗以实现观察等待
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Reply to "Intensifying Neoadjuvant Therapy for Rectal Cancers Towards Watchful Waiting," by Chakrabarti, Deep, et al.
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Watch and wait for rectal cancer: where are we really at?观察等待直肠癌：我们究竟处于什么阶段？
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[Analysis on efficacy and safety of total neoadjuvant therapy in patients with locally advanced rectal cancer with high risk factors].[局部晚期高危直肠癌患者新辅助综合治疗的疗效与安全性分析]
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Opinions have changed on the management of rectal cancer with a complete clinical response to neoadjuvant chemoradiotherapy.对于经新辅助放化疗后出现完全临床缓解的直肠癌的管理，人们的看法已经发生了改变。
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Delaying surgery after neoadjuvant chemoradiotherapy in rectal cancer has no influence in surgical approach or short-term clinical outcomes.新辅助放化疗后延迟直肠癌手术不会影响手术方式或短期临床结局。
Eur J Surg Oncol. 2018 Apr;44(4):484-489. doi: 10.1016/j.ejso.2018.01.088. Epub 2018 Feb 2.

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Sci Rep. 2022 Mar 17;12(1):4617. doi: 10.1038/s41598-022-08541-1.

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Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.短程放疗联合化疗后行全直肠系膜切除术（TME）与术前放化疗、TME 及辅助化疗在局部进展期直肠癌（RAPIDO）中的应用：一项随机、开放标签、3 期临床试验。
Lancet Oncol. 2021 Jan;22(1):29-42. doi: 10.1016/S1470-2045(20)30555-6. Epub 2020 Dec 7.
2
Avoiding Unnecessary Major Rectal Cancer Surgery by Implementing Structural Restaging and a Watch-and-Wait Strategy After Neoadjuvant Radiochemotherapy.通过实施新辅助放化疗后的结构性重新分期和观察等待策略，避免不必要的主要直肠癌手术。
Ann Surg Oncol. 2021 May;28(5):2811-2818. doi: 10.1245/s10434-020-09192-0. Epub 2020 Nov 10.
3
Total neoadjuvant therapy for locally advanced rectal cancer: the fuse is lit.局部晚期直肠癌的全新辅助治疗：导火索已点燃。
Br J Surg. 2020 Dec;107(13):1705-1707. doi: 10.1002/bjs.12014. Epub 2020 Oct 26.
4
Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study.长程术前放化疗与 5×5 Gy 放疗加巩固化疗治疗临床 T4 和固定临床 T3 直肠癌：波兰 II 期随机研究的长期结果。
Ann Oncol. 2019 Aug 1;30(8):1298-1303. doi: 10.1093/annonc/mdz186.
5
Tumour regression after radiotherapy for rectal cancer - Results from the randomised Stockholm III trial.直肠癌放疗后肿瘤消退——来自随机斯德哥尔摩 III 试验的结果。
Radiother Oncol. 2019 Jun;135:178-186. doi: 10.1016/j.radonc.2019.03.016. Epub 2019 Apr 1.
6
Total neoadjuvant therapy for rectal cancer.直肠癌的全新辅助治疗
Cancer Radiother. 2018 Sep;22(5):459-465. doi: 10.1016/j.canrad.2018.01.004. Epub 2018 May 26.
7
Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study.长程基于奥沙利铂的术前放化疗与 5×5 Gy 和巩固化疗治疗 cT4 或固定 cT3 直肠癌：一项随机 III 期研究的结果。
Ann Oncol. 2016 May;27(5):834-42. doi: 10.1093/annonc/mdw062. Epub 2016 Feb 15.
8
Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial.术前放疗与手术间隔时间对直肠癌降期及保肛手术率的影响：里昂R90-01随机试验
J Clin Oncol. 1999 Aug;17(8):2396. doi: 10.1200/JCO.1999.17.8.2396.