Cimino J A, Noto R A, Fusco C L, Cooperman J M
Department of Community and Preventive Medicine, New York Medical College, Valhalla 10595.
Am J Clin Nutr. 1988 Mar;47(3):481-3. doi: 10.1093/ajcn/47.3.481.
In the hypothyroid rat the flavin adenine dinucleotide (FAD) content of the liver is similar to that observed in rats maintained on a riboflavin-deficient diet. Thyroxine regulates the enzyme flavin kinase. Human adults with hypothyroidism have levels of erythrocyte glutathione reductase (EGR), an FAD-containing enzyme, in the range indicative of riboflavin deficiency, which can be corrected with thyroxine therapy. In the present study six newborns with severe congenital hypothyroidism because of athyrosis, ectopic thyroidism, or congenital hypothyroidism with Down's syndrome had normal levels of EGR, and treatment with thyroxine had no effect on these levels.
在甲状腺功能减退的大鼠中，肝脏中黄素腺嘌呤二核苷酸（FAD）的含量与维持在核黄素缺乏饮食的大鼠中观察到的相似。甲状腺素调节黄素激酶。患有甲状腺功能减退的成年人体内，红细胞谷胱甘肽还原酶（EGR，一种含FAD的酶）水平处于表明核黄素缺乏的范围内，甲状腺素治疗可纠正该情况。在本研究中，六名因甲状腺缺如、异位甲状腺或患有唐氏综合征的先天性甲状腺功能减退而患有严重先天性甲状腺功能减退的新生儿，其EGR水平正常，甲状腺素治疗对这些水平没有影响。
