Luan Eng L I, Ng T, Wan W P, Ganesan J
Br J Haematol. 1975 Nov;31(3):337-42. doi: 10.1111/j.1365-2141.1975.tb00864.x.
A study of glutathione reductase (GR) activity and its stimulation by flavin adenine dinucleotide (FAD) in erythrocytes of Malaysian newborns and adults of different racial groups showed that GR stimulation by FAD was greater than 20% in 50% of 866 newborns (57% of Malays, 55% of Indians and 41% of Chinese) and 54% of 274 adults (46% of Malays, 65% of Indians and 45% of Chinese). There was a significant negative correlation between GR activity and percentage FAD stimulation in both newborns and adults in all racial groups. Low GR activity and a high percentage FAD stimulation were more prevalent among parents of newborns with low GR activity than among parents of newborns with higher GR activity. Administration of riboflavin to mothers with low GR activity resulted in increased GR activity and a decreased percentage of FAD stimulation. None of the individuals examined had clear clinical manifestations of riboflavin deficiency. It is concluded that subclinical riboflavin deficiency leading to low GR activity is prevalent in Malaysia among adults and newborns, especially among Malays and Indians.
一项关于马来西亚不同种族新生儿和成年人红细胞中谷胱甘肽还原酶（GR）活性及其受黄素腺嘌呤二核苷酸（FAD）刺激情况的研究表明，在866名新生儿中的50%（马来人占57%，印度人占55%，中国人占41%）以及274名成年人中的54%（马来人占46%，印度人占65%，中国人占45%）中，FAD对GR的刺激作用大于20%。在所有种族群体的新生儿和成年人中，GR活性与FAD刺激百分比之间均存在显著的负相关。GR活性低且FAD刺激百分比高的情况在GR活性低的新生儿的父母中比在GR活性较高的新生儿的父母中更为普遍。对GR活性低的母亲给予核黄素后，GR活性增加，FAD刺激百分比降低。所有接受检查的个体均无明显的核黄素缺乏临床表现。得出的结论是，导致GR活性低的亚临床核黄素缺乏在马来西亚的成年人和新生儿中普遍存在，尤其是在马来人和印度人中。
