Schröder S, Schwarz W, Rehpenning W, Löning T, Böcker W
Institute of Pathology, University of Hamburg, Germany.
Am J Clin Pathol. 1988 Mar;89(3):295-300. doi: 10.1093/ajcp/89.3.295.
Paraffin sections of 106 primary thyroid carcinomas were the subject of an immunocytochemical study to determine the density of infiltrates of S-100 protein-positive dendritic/Langerhans cells (LC), lysozyme-positive histiocytes, and LCA-positive lymphocytes. Evidence of dense infiltrates of LCs was found only in the majority of papillary thyroid carcinomas (PCs). The determination of the quantity of LCs proved to be a highly effective means of assessing the prognosis of these tumors. Irrespective of other morphologic and clinical features, no single instance of death resulting from cancer occurred among 23 PCs with dense LC infiltrates (including 6 tumors of stage pT4), while 9 of 53 (17%) of the remaining patients ultimately died from thyroid cancer. On the other hand, the degree of histiocytic and lymphocytic infiltrations was not associated with a distinct biologic behavior neither among PC nor among the remaining thyroid carcinomas. These findings suggest that LCs may play an important role in the immunologic defense mechanisms of the host against the tumor only in the papillary type of thyroid cancer.
对106例原发性甲状腺癌的石蜡切片进行免疫细胞化学研究，以确定S-100蛋白阳性树突状/朗格汉斯细胞（LC）、溶菌酶阳性组织细胞和LCA阳性淋巴细胞的浸润密度。仅在大多数甲状腺乳头状癌（PC）中发现LC密集浸润的证据。LC数量的测定被证明是评估这些肿瘤预后的一种高效方法。无论其他形态学和临床特征如何，23例有密集LC浸润的PC患者（包括6例pT4期肿瘤）中无一例死于癌症，而其余53例患者中有9例（17%）最终死于甲状腺癌。另一方面，组织细胞和淋巴细胞浸润程度与PC以及其他甲状腺癌的独特生物学行为均无关联。这些发现表明，LC可能仅在甲状腺乳头状癌中对宿主抵抗肿瘤的免疫防御机制起重要作用。
