Malmström M, Konttinen Y T, Jungell P, Bergroth V, Segerberg-Konttinen M, Nordström D
Department of Oral and Maxillofacial Surgery, Helsinki University, Finland.
Am J Clin Pathol. 1988 Mar;89(3):329-34. doi: 10.1093/ajcp/89.3.329.
The current study evaluated the activation of T-cell mediated cellular immune response in the oral lesions in lichen planus (OLP). Analysis was made of the ultramorphology, lymphocyte activation marker expression, DNA synthesis, and gamma-interferon production of the inflammatory cells in OLP lesions. According to these four different aspects of lymphocyte activation, only a minor fraction, 5% at the most, of all T-cells in situ were activated. This minor fraction, however, not the resting T-cells without these signs of activation, may decide the outcome of the local immune-inflammatory process in OLP. Of the inflammatory cells in situ, however, 81 +/- 5% were Ia positive. This finding may be the result of an Ia inducing capacity of the gamma-interferon produced locally by the activated T-cells.
本研究评估了扁平苔藓（OLP）口腔损害中T细胞介导的细胞免疫反应的激活情况。对OLP损害中炎症细胞的超微形态、淋巴细胞激活标志物表达、DNA合成及γ干扰素产生进行了分析。根据淋巴细胞激活的这四个不同方面，原位所有T细胞中只有一小部分（最多5%）被激活。然而，这一小部分激活的T细胞而非没有这些激活迹象的静止T细胞，可能决定OLP局部免疫炎症过程的结果。不过，原位炎症细胞中81±5%为Ia阳性。这一发现可能是激活的T细胞局部产生的γ干扰素具有Ia诱导能力的结果。
