Kilpi A M
Scand J Dent Res. 1987 Apr;95(2):174-80. doi: 10.1111/j.1600-0722.1987.tb01826.x.
Monoclonal activation markers (Ia, Tac, T9, and 4F2) were used to detect the degree of activation of mononuclear cells in the inflammatory infiltrates of oral lichen planus in situ. In addition the specimens were stained with the following monoclonal antibodies: T4, T8, T11, M1, and pan-B. T-lymphocyte was the predominant cell type in the inflammatory infiltrates. According to the results of the activation marker analysis, the majority of the T-lymphocytes were resting. However, activated cytotoxic T8 and 4F2 T-cells were located close to damaged basal cells; this finding may suggest that they are responsible for the damage and supports the claim that a cell-mediated immune response participates actively in local pathogenetic mechanisms in oral lichen planus.
使用单克隆激活标志物（Ia、Tac、T9和4F2）原位检测口腔扁平苔藓炎症浸润中单核细胞的激活程度。此外，标本还用以下单克隆抗体染色：T4、T8、T11、M1和泛B。T淋巴细胞是炎症浸润中的主要细胞类型。根据激活标志物分析结果，大多数T淋巴细胞处于静止状态。然而，活化的细胞毒性T8和4F2 T细胞位于受损基底细胞附近；这一发现可能表明它们与损伤有关，并支持细胞介导的免疫反应积极参与口腔扁平苔藓局部发病机制的观点。
