Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China.
Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi'an, China; University Institute of Physical Therapy, University of Lahore, Lahore, Pakistan.
Life Sci. 2021 Mar 15;269:119097. doi: 10.1016/j.lfs.2021.119097. Epub 2021 Jan 19.
Exercise and food supplement of vitamin C (VC) are beneficial to human health, especially for those who suffer from hypertension. Here we tend to explore if gut microflora is involved in the anti-hypertensive effects of exercise and VC-supplement therapies.
With the spontaneously hypertensive rat (SHR) model, the small intestine pathology and the fecal microbiota was analyzed along with the pro- and anti-inflammatory cytokines (PICs and AICs) and reactive oxygen species (ROS) in the hypothalamus paraventricular nucleus (PVN) and intestine.
We found that both exercise and VC intake, individually or combined, were able to alleviate the blood pressure in the SHRs comparing to the normotensive control Wistar-kyoto (WKY) rats. The expression level of PICs in the PVN and intestine of the SHRs was down-regulated while the AICs were up-regulated after treatments, together with down-regulation of ROS in the PVN. At meantime, the gut pathology was dramatically improved in the SHRs with exercise training or VC intake. Analysis of the gut microflora revealed significant changes in their composition. Several important micro-organisms that were deficient in the SHRs were found up-regulated by the treatments, including Turicibacter and Romboutsia which are involved in the short-chain fatty acid production.
Exercise training and VC intake individually can modify the gut microflora composition and improve the inflammatory state in both PVN and intestine, which contribute to their anti-hypertensive function. Combination of the two treatments enhanced their effects and worth to be considered as a non-medical aid for the hypertensive patients.
运动和维生素 C（VC）的食物补充有益于人类健康，尤其对高血压患者有益。在这里，我们试图探讨肠道微生物群是否参与运动和 VC 补充治疗的抗高血压作用。
使用自发性高血压大鼠（SHR）模型，分析小肠病理学和粪便微生物群，以及下丘脑室旁核（PVN）和肠道中的促炎和抗炎细胞因子（PICs 和 AICs）和活性氧（ROS）。
我们发现，运动和 VC 摄入，单独或联合使用，均能降低 SHR 血压，与正常血压的 Wistar-kyoto（WKY）大鼠相比。治疗后，SHR 中 PVN 和肠道中的 PICs 表达水平下调，而 AICs 上调，同时 PVN 中的 ROS 下调。与此同时，运动训练或 VC 摄入可显著改善 SHR 的肠道病理学。肠道微生物群分析显示其组成发生了显著变化。在 SHR 中缺乏的几种重要微生物被发现通过治疗上调，包括 Turicibacter 和 Romboutsia，它们参与短链脂肪酸的产生。
运动训练和 VC 摄入单独可以改变肠道微生物群的组成，并改善 PVN 和肠道中的炎症状态，这有助于它们的抗高血压功能。两种治疗方法的联合增强了它们的效果，值得作为高血压患者的非药物辅助治疗。
