Department of Chemistry, University of South Alabama, Mobile, AL, United States.
Department of Biomedical Sciences, University of South Alabama, Mobile, AL, United States.
Bioorg Med Chem Lett. 2021 Mar 15;36:127808. doi: 10.1016/j.bmcl.2021.127808. Epub 2021 Jan 19.
Commercial disinfectants are routinely used to decontaminate surfaces where microbes are expected and unwelcome. Several disinfectants contain quaternary ammonium salts, or "quats", all being derived from ammonium. Quaternary alkyl dimethyl benzyl ammonium chloride or bromide disinfectants are widely available. These compounds are effective in reducing or eliminating bacteria on contaminated nonporous surfaces. A unique benzyl derived boronium salt with strong detergent action has been developed. It demonstrated 4-8X greater antibacterial activity against 3 different bacteria when compared to an equal concentration of a commercial quant disinfectant solution containing alkyl dimethyl benzyl ammonium chloride and alkyl dimethyl ethylbenzyl ammonium chloride. Antibacterial effectiveness of each agent was determined by the minimum inhibitory concentration (MIC) method.
商业消毒剂通常用于消毒预期存在和不受欢迎的微生物的表面。几种消毒剂含有季铵盐,或“季铵化合物”,全部由铵衍生而来。季铵盐消毒剂广泛可用,其中包括烷基二甲基苄基氯化铵或溴化物。这些化合物在减少或消除污染的非多孔表面上的细菌方面非常有效。已经开发出一种具有强去污作用的独特苄基衍生的硼盐。与含有烷基二甲基苄基氯化铵和烷基二甲基乙基苄基氯化铵的商业季铵消毒剂溶液相比,当浓度相同时,该盐对 3 种不同细菌的抗菌活性高 4-8 倍。每种试剂的抗菌效果通过最低抑菌浓度(MIC)方法确定。